AGE-DEPENDENT FEATURES OF THE BONE MARROW RESPONSE TO TOXICOGENIC LIVER FIBROSIS IN THE EXPERIMENT

Ievgen  Ivanov; Anastasiia Bondar; Anatoly Bozhkov

doi:10.36074/logos-01.03.2024.031

Biology and Biotechnology

March 1, 2024; Paris, France: VI International Scientific and Practical Conference «DÉBATS SCIENTIFIQUES ET ORIENTATIONS PROSPECTIVES DU DÉVELOPPEMENT SCIENTIFIQUE»

AGE-DEPENDENT FEATURES OF THE BONE MARROW RESPONSE TO TOXICOGENIC LIVER FIBROSIS IN THE EXPERIMENT

Ievgen Ivanov ⁺⁻
Anastasiia Bondar ⁺⁻
Anatoly Bozhkov ⁺⁻

DOI: https://doi.org/10.36074/logos-01.03.2024.031
Published: 08.03.2024

Abstract

Liver fibrosis has been shown to affect bone marrow cell morphotypes. This study investigated the response of bone marrow cells to fibrosis. Bone marrow cells from rats of different ages were the object of study. It was shown that the proliferative activity of bone marrow cells in animals with Cu-induced fibrosis was significantly lower than in animals with CCl₄-induced liver fibrosis. Bone marrow plays an important role in the development of liver fibrosis.

References

Tapper, E. B., & Parikh, N. D. (2018). Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study. bmj, 362.
Pellicoro, A., Ramachandran, P., & Iredale, J. P. (2012, December). Reversibility of liver fibrosis. In Fibrogenesis & tissue repair (Vol. 5, No. 1, pp. 1-4). BioMed Central.
Sun, M., & Kisseleva, T. (2015). Reversibility of liver fibrosis. Clinics and research in hepatology and gastroenterology, 39, S60-S63.
Bozhkov, A. I., Novikova, A. V., Klimova, E. M., Ionov, I. A., Akzhyhitov, R. A., Kurhuzova, N. I., ... & Haiovyi, S. S. (2023). Vitamin A reduces the mortality of animals with induced liver fibrosis by providing a multi-level body defense system. Journal of Clinical and Experimental Hepatology, 13(1), 48-63.
Bozhkov, A., Ionov, I., Kurhuzova, N., Novikova, A., Katerynych, О., & Akzhyhitov, R. (2022). Vitamin A intake forms resistance to hypervitaminosis A and affects the functional activity of the liver. Clinical Nutrition Open Science, 41, 82-97.
Amend, S. R., Valkenburg, K. C., & Pienta, K. J. (2016). Murine hind limb long bone dissection and bone marrow isolation. JoVE (Journal of Visualized Experiments), (110), e53936.
Lewandowski, K., Kowalik, M. M., Pawlaczyk, R., Rogowski, J., & Hellmann, A. (2012). Microscopic examination of bone marrow aspirate in healthy adults–comparison of two techniques of slide preparation. International journal of laboratory hematology, 34(3), 254-261.
Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O. (2015). Calcium and ROS: A mutual interplay. Redox biology, 6, 260-271.

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Ivanov , I. ., Bondar , A., & Bozhkov , A. (2024). AGE-DEPENDENT FEATURES OF THE BONE MARROW RESPONSE TO TOXICOGENIC LIVER FIBROSIS IN THE EXPERIMENT. Collection of Scientific Papers «ΛΌГOΣ», (March 1, 2024; Paris, France), 126–134. https://doi.org/10.36074/logos-01.03.2024.031

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[1] Tapper, E. B., & Parikh, N. D. (2018). Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study. bmj, 362.

[2] Pellicoro, A., Ramachandran, P., & Iredale, J. P. (2012, December). Reversibility of liver fibrosis. In Fibrogenesis & tissue repair (Vol. 5, No. 1, pp. 1-4). BioMed Central.

[3] Sun, M., & Kisseleva, T. (2015). Reversibility of liver fibrosis. Clinics and research in hepatology and gastroenterology, 39, S60-S63.

[4] Bozhkov, A. I., Novikova, A. V., Klimova, E. M., Ionov, I. A., Akzhyhitov, R. A., Kurhuzova, N. I., ... & Haiovyi, S. S. (2023). Vitamin A reduces the mortality of animals with induced liver fibrosis by providing a multi-level body defense system. Journal of Clinical and Experimental Hepatology, 13(1), 48-63.

[5] Bozhkov, A., Ionov, I., Kurhuzova, N., Novikova, A., Katerynych, О., & Akzhyhitov, R. (2022). Vitamin A intake forms resistance to hypervitaminosis A and affects the functional activity of the liver. Clinical Nutrition Open Science, 41, 82-97.

[6] Amend, S. R., Valkenburg, K. C., & Pienta, K. J. (2016). Murine hind limb long bone dissection and bone marrow isolation. JoVE (Journal of Visualized Experiments), (110), e53936.

[7] Lewandowski, K., Kowalik, M. M., Pawlaczyk, R., Rogowski, J., & Hellmann, A. (2012). Microscopic examination of bone marrow aspirate in healthy adults–comparison of two techniques of slide preparation. International journal of laboratory hematology, 34(3), 254-261.

[8] Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O. (2015). Calcium and ROS: A mutual interplay. Redox biology, 6, 260-271.