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Biology and Biotechnology

October 14, 2022; Oxford, UK: IV International Scientific and Practical Conference «THEORETICAL AND EMPIRICAL SCIENTIFIC RESEARCH: CONCEPT AND TRENDS»


INHIBITION OF LACTATE DEHYDROGENASE REDUCES THE SURVIVAL OF METASTATICALLY ACTIVE LEWIS LUNG CARCINOMA CELLS


DOI
https://doi.org/10.36074/logos-14.10.2022.11
Published
21.10.2022

Abstract

Most tumors are characterized by increased glucose uptake and lactate production, a phenomenon known as aerobic glycolysis. Active glucose uptake and glycolysis can provide the synthesis of basic metabolites required for proliferation. The final step in aerobic glycolysis is the NADH-dependent reduction of pyruvate to lactate with the participation of lactate dehydrogenase (LDH) [1-5]. It has been shown that inhibition of LDH activity can reduce lactate production, slow down the growth of tumor cells in vitro and in vivo modulation of immune responses [6-10], but there are practically no studies elucidating the role of LDH in tumor dissemination.

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