This article substantiates the concept of financial and digital de-risking of innovative projects in Ukraine's strategic sectors through the synergy of two original mechanisms. The Institute of State Innovation Support (IDIS) is the central financial mechanism: a revolving fund with standardised verified packages and a differentiated guarantee deposit reduces the cost of capital, raises the IRR of a typical project from 8–12% to 14–18%, and delivers a financial multiplier of 3–5x. The e-hryvnia/CBDC serves as the auxiliary trust-building mechanism: oracle verification of results and real-time donor access to the DLT registry further reduce the risk premium by 2–4 percentage points, raising the multiplier to 5–8x. A comparative analysis with Innovate UK, EIC Accelerator, ARPA-E and Fraunhofer Venture confirms the uniqueness of IDIS as a self-sustaining de-risking mechanism compatible with EU State Aid rules.