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Biology and Biotechnology

March 31, 2023; Zurich, Switzerland: IV International Scientific and Practical Conference «GRUNDLAGEN DER MODERNEN WISSENSCHAFTLICHEN FORSCHUNG»


THE MICROBIOTA COMPOSITION OF REPRODUCTIVE TRACT OF WOMENWITH DIFFERENT PATHOLOGIES


DOI
https://doi.org/10.36074/logos-31.03.2023.20
Published
11.04.2023

Abstract

The aim of research was to analyze the frequency of detection of dysbiotic states of the reproductive tract of women with different pathologies. It was established the presence of dysbiotic disorders of the II and III degrees according to the manifestation of bacterial vaginosis and urogenital candidiasis in 100% of cases in patients with malignant neoplasms and pregnant women with cervical cancer in situ; the frequency of dysbiosis detection in pregnant women was 31% and in women with miscarriage – 58% of cases. The obtained data made Escherichia coli, Candida albicans, Gardnerella vaginalis are the dominant etiopathogenic agents of genital microbiota disorders and the cause of reproductive system imbalance in women of all risk categories.

References

  1. Chen, X., Lu, Yu., Chen, T. & Li, R. (2021). The female vaginal microbiome in health and bacterial vaginosis. Frontiers in Cellular and Infection Microbiology, (11), 1-15. https://doi.org/10.3389/fcimb.2021.631972
  2. Green, K. A., Zarek, S. M. & Catherino, W. H. (2015). Gynecologic health and disease in relation to the microbiome of the female reproductive tract. Fertility and Sterility, (104), 1351-1357. https://doi.org/10.1016/j.fertnstert.2015.10.010
  3. Punzón-Jiménez, P. & Labarta, E. (2021). The impact of the female genital tract microbiome in women's health and reproduction: a review. Journal of Assisted Reproduction and Genetics, (38), 2519-2541. https//doi.org/10.1007/s10815-021-02247-5
  4. Vitale, S. G., Ferrari, F., Ciebiera, M., Zgliczyńska, M., Rapisadra, A. M. Ch., Vecchio, G. M., Pino, A., Angelico, G., Knafel, A., Riemma, G., De Franciscis, P. & Cianci, S. (2022). The role of genital tract microbiome in fertility: a systematic review. International Journal of Molecular Sciences, 23(1), 180. https://doi.org/10.3390/ijms23010180
  5. Kalia, N., Singh, J. & Kaur, M. (2020). Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review. Annals of Clinical Microbiology and Antimicrobials, (19), 5. https://doi.org/10.1186/s12941-020-0347-4
  6. Bagga, R. & Arora, P. (2020). Genital Micro-Organisms in Pregnancy. Frontiers in Public Health, (8), 225. https://doi.org/10.3389/fpubh.2020.00225
  7. Haahr, T., Jensen, J. S., Thomsen, L., Duus, L., Rygaard, K. & Humaidan P. (2016). Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients. Human Reproduction, 31(4), 795-803. https://doi.org/10.1093/humrep/dew026
  8. Smolarczyk, K., Mlynarczyk-Bonikowska, B., Rudnicka, E., Szukiewicz, D., Meczekalski, B., Smolarczyk, R. & Pieta, W. (2021). The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility. International Journal of Molecular Sciences, 22(4), 2170. https://doi.org/10.3390/ijms22042170
  9. Haahr, Thor., Clausen, T. D., Thorsen, J., Rasmussen, M. A., Mortensen, M. S., Lehtimäki, J., Shah, S. A., Hjelmso, M. H., Bonnelykke, K., Chawes, Bo. L., Vestergaard, G., Jacobsson, Bo., Larsson, P.-G., Brix, S., Sorensen, S. J., Bisgaard, H. & Stokhol, J. (2022). Vaginal dysbiosis in pregnancy associates with risk of emergency caesarean section: a prospective cohort study. Clinical Microbiology and Infection, 28(4), 588-595. https://doi.org/10.1016/j.cmi.2021.08.028
  10. Kovachev, S. M. (2020). Cervical cancer and vaginal microbiota changes. Archives of Microbiology, (202), 323-327. https://doi.org/10.1007/s00203-019-01747-4