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Biology and Biotechnology

March 29, 2024; Cambridge, UK: VI International Scientific and Practical Conference «EDUCATION AND SCIENCE OF TODAY: INTERSECTORAL ISSUES AND DEVELOPMENT OF SCIENCES»


LONG-CHAIN N-SUBSTITUTED IMIDAZOLE DERIVATIVES WITH ANTICANCER ACTIVITY AGAINST CHRONIC MYELOID LEUKEMIA


DOI
https://doi.org/10.36074/logos-29.03.2024.041
Published
06.04.2024

Abstract

According to statistics, chronic myelogenous leukemia (CML) accounts for about 15% of the total quantity of leukemias and is characterized by a
significantly increased number of granulocytes in the blood [1]. CML is described by a 3-phase course of the disease, treatment in each subsequent phase
becomes more resistant to drugs. The development of the selective Bcr-Abl tyrosine kinase inhibitor Imatinib has improved the treatment of patients with CML, however, several patients do not tolerate, or develop resistance to Imatinib [2]. Therefore, the development of new approaches to the treatment of CML is an important task.

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