Introduction. Tumorous formations are one of the leading causes of morbidity and mortality worldwide, and their clinical manifestations can vary significantly depending on the size, localization, and biological characteristics. The relationships between the tumor volume and clinical symptomatology remain insufficiently studied, which complicates early diagnosis and prognosis of the disease course. Establishing a correlation between tumor size and clinical manifestations may improve patient stratification, optimize treatment strategies, and enhance therapy effectiveness[1].