Introduction. Due to ART, the life expectancy and life quality of people living with HIV (PLHIV) can be compared with HIV negative people, so it is important to consider the main issues of primary care for adult PLHIV. Measures to ensure the health of PLHIV include immunization, which is a priority in health policy in developed countries. Diphtheria is a disease that is effectively managed with immunoprophylaxis [1, 2, 3].